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Gabapentin Mechanism of Action

Gabapentin was designed to mimic the neurotransmitter GABA. It does not, however, bind to GABA receptors. Its mechanism of action as an antiepileptic agent likely involves its inhibition of the alpha 2-delta subunit of voltage-gated calcium channels . It was first approved as an anticonvulsant in 1994 in the US and is now available worldwide.  It was also approved in… Continue reading Gabapentin Mechanism of Action